The Effect of Intra-articular Corticosteroids on Articular Cartilage
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چکیده
منابع مشابه
The Effect of Intra-articular Corticosteroids on Articular Cartilage
BACKGROUND Intra-articular (IA) corticosteroid therapy has been used for the treatment of inflammation and pain in the knee since the 1950s. PURPOSE To review the current literature on the effects of IA corticosteroids on articular cartilage. STUDY DESIGN Systematic review. METHODS A MEDLINE and SCOPUS database search was performed, and studies were selected for basic science and clinical...
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We have investigated the effects of intra-articular (i.a.) administration of ketorolac in the rat knee joint. Thirty Sprague-Dawley rats were given 0.25 ml of a standard preparation of ketorolac trometamol (10 mg ml-1) by injection into the right knee joint and 0.25 ml of 0.9% physiological saline solution by injection into the left knee as a control. Ten rats were killed at 24 h, 10 at 48 h an...
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An attempt was made to ascertain whether intra-articular corticosteroids exert a harmful effect on primate cartilage. The knee joints of 10 Macaca irus monkeys were subjected to either one, two, or six injections of 20 mg methyl prednisolone or an equal number of control injections over a 12-week period. Minor degenerative changes of many femoral condyles were shown by India ink staining and by...
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The action of corticosteroids is exerted through steroid-specific receptors in the cytoplasm of steroidresponsive tissues. This interaction results in the altered transcription of genes, leading to a wide variety of anti-inflammatory effects as well as other effects on the biology of articular cells that are of variable benefit. Corticosteroids are able to suppress inflammation at virtually all...
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Objective: Magnesium sulfate has been shown to provide analgesia when administered into the knee joints. The aim of this study was to evaluate the histopathological effects of intraarticular administration of magnesium sulfate in the rat knee joint. Design: A total of 50 rats were given 0.25ml of magnesium sulfate (10%) by injection into the right knee joint and 0.25ml of 0.9% saline solution b...
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ژورنال
عنوان ژورنال: Orthopaedic Journal of Sports Medicine
سال: 2015
ISSN: 2325-9671,2325-9671
DOI: 10.1177/2325967115581163